The Potential Role of RNA "Writer" TRMT61B in the Immune Regulation of Breast Cancer

Puzhen Wu, Youjia Zhou, Wenting Luo, Longyuan Wu

Abstract: Complex signatures expressed at the genetic, transcriptional, and epigenetic levels influence tumorigenesis and evolution in breast cancer. A growing body of evidence supports the close association of RNA modification with the epigenetic regulation of the immune response. However, the mechanism of RNA modification “writers” in the immunity of breast cancer remains indeterminacy. We analyzed genomic alterations in 8236 breast cancer samples from the cBio portal database. Correlations between RNA “writers” and the expression of immunomodulators, including immunosuppressants, immunostimulants, and MHC molecules, were calculated using the TIMER and TISIDB databases. Our analysis confirmed that abnormalities in four classes of RNA “writers” were significantly correlated with poor prognosis in breast cancer. In addition, abnormal expression of TRMT61B, a tumor-associated RNA “writer”, may be associated with patients prognosis, immune infiltration levels, and expression of immunomodulators in breast cancer patients. Our results suggest that TRMT61B may serve as a biological marker of breast cancer prognosis and a potential drug target, providing a novel idea for the future therapy of breast cancer.