Participatory Design of a Clinical Trial Eligibility Criteria Simplification Method

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Yilu Fang, Jae Hyun Kim, Betina Ross S. Idnay, Rebeca Aragon Garcia, Carmen E. Castillo, Yingcheng Sun, Hao Liu, Cong Liu, Chi Yuan, Chunhua Weng

Published: 2021, Last Modified: 11 Feb 2026MIE 2021EveryoneRevisionsBibTeXCC BY-SA 4.0
Abstract: Clinical trial eligibility criteria are important for selecting the right participants for clinical trials. However, they are often complex and not computable. This paper presents the participatory design of a human-computer collaboration method for criteria simplification that includes natural language processing followed by user-centered eligibility criteria simplification. A case study on the ARCADIA trial shows how criteria were simplified for structured database querying by clinical researchers and identifies rules for criteria simplification and concept normalization.