Gene Expression Regulation in E-Cell Model Analog-Cell

Xiaosong Han, Xinhua Lu, Chunguo Wu, Yanchun Liang

Abstract: Analog-Cell was proposed in 2007, which could be used to graphically simulate the processes of gene expression including transcription, translation and gene mutation on the molecule level and might be the first pattern model of E-Cell in China as what we know. Due to the importance in processes of gene expression regulation, some regulation factors, enzymes and their reaction mechanisms are integrated into Analog-Cell to simulate the life activities of biological cells more lively and more accurately, and discover new biological rules as well. Numerical experiment results indicate that the extended Analog-Cell could simulate gene expression regulation effectively. As one of the most important regulation elements, promoter and its predictions method are also introduced to our proposed model, which enables the functions of the extended Analog-Cell to be more reasonable and practical.