GrEp: Graph-based epithelial cell classification refinement in histopathology H&E images

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Ana Leni Frei, Javier Garcia-Baroja, Tilman T. Rau, Christina Neppl, Alessandro Lugli, Wiebke Solass, Martin Wartenberg, Andreas Fischer, Inti Zlobec

Published: 01 Jan 2026, Last Modified: 12 Nov 2025Pattern Recognit. 2026EveryoneRevisionsBibTeXCC BY-SA 4.0
Abstract: Highlights•A novel graph-based workflow for the subclassification of epithelial cells into normal and malignant.•Node feature extraction using GammaFocus tile augmentation.•A clustering and median filtering post-processing to smooth predictions inside individual epithelial glands.•Expansion from colorectal tissue to two unseen tissue types (endometrium and pancreas).