DDEvENet: Evidence-based ensemble learning for uncertainty-aware brain parcellation using diffusion MRI

Chenjun Li, Dian Yang, Shun Yao, Shuyue Wang, Ye Wu, Le Zhang, Qiannuo Li, Kang Ik Kevin Cho, Johanna Seitz-Holland, Lipeng Ning, Jon Haitz Legarreta, Yogesh Rathi, Carl-Fredrik Westin, Lauren J. O'Donnell, Nir A. Sochen, Ofer Pasternak, Fan Zhang

Abstract: Highlights•A deep learning framework to quantify predictive uncertainty in dMRI parcellation•A novel evidence-based ensemble method to integrate multiple uncertainty estimates•Output uncertainty heatmap identification that can highlight abnormal brain regions•Improved parcellation accuracy and interpretability compared to conventional methods