Score-Based Diffusion Models for Photoacoustic Tomography Image Reconstruction

Sreemanti Dey, Snigdha Saha, Berthy Feng, Manxiu Cui, Laure Delisle, Oscar Leong, Lihong Wang, Katherine Bouman

Abstract: Photoacoustic tomography (PAT) is a rapidly-evolving medical imaging modality that combines optical absorption contrast with ultrasound imaging depth. One challenge in PAT is image reconstruction with inadequate acoustic signals due to limited sensor coverage or due to the density of the transducer array. Such cases call for solving an ill-posed inverse reconstruction problem. In this work, we use score-based diffusion models to solve the inverse problem of reconstructing an image from limited PAT measurements. The proposed approach allows us to incorporate an expressive prior learned by a diffusion model on simulated vessel structures while still being robust to varying transducer sparsity conditions.