HistoMSC: Density and topology analysis for AI-based visual annotation of histopathology whole slide images

Zahoor Ahmad, Khaled Al-Thelaya, Mahmood Alzubaidi, Faaiz Joad, Nauman Ullah Gilal, William Mifsud, Sabri Boughorbel, Giovanni Pintore, Enrico Gobbetti, Jens Schneider, Marco Agus

Abstract: Highlights•AI-driven annotation for whole slide histopathology images.•Deep learning models for accurate nuclei localization & classification.•Multi-scale density analysis using Kernel Density Estimation (KDE).•Innovative use of Morse–Smale Complex for tissue topology analysis.•Enhances pathologist efficiency with automated, scalable visual tools.

External IDs:doi:10.1016/j.compbiomed.2025.109991