Spatiotemporal network coding of physiological mossy fiber inputs by the cerebellar granular layer

Shyam Kumar Sudhakar, Sungho Hong, Ivan Raikov, Rodrigo Publio, Claus Lang, Thomas G. Close, Daqing Guo, Mario Negrello, Erik De Schutter

Abstract: Author summary The cerebellum is an organ of peculiar geometrical properties, and has been attributed the function of applying spatiotemporal transforms to sensorimotor data since Eccles. In this work we have analyzed the spatiotemporal response properties of the first part of the cerebellar circuit, the granule layer. On the basis of a biophysically plausible and large-scale model of the cerebellum, constrained by a wealth of anatomical data, we study the network dynamics and firing properties of individual cell populations in response to 'realistic' input patterns. We make specific predictions about the spatiotemporal features of granule layer processing regarding the effects of the gap junction coupled network of Golgi cells on a spatially restricted input, in an effect we denominate first-takes-all. Furthermore, we calculate that the granule cell layer has a wide dynamic range, indicating that this is a system that can transmit large variations of input intensities.