Analysis of cell cycle dynamics using probabilistic cell cycle models

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Evren Gurkan-Cavusoglu, Jane E. Schupp, Timothy J. Kinsella, Kenneth A. Loparo

Published: 2011, Last Modified: 30 Jul 2025EMBC 2011EveryoneRevisionsBibTeXCC BY-SA 4.0
Abstract: In this study, we develop asynchronous probabilistic cell cycle models to quantitatively assess the effect of ionizing radiation on a human colon cancer cell line. We use both synchronous and asynchronous cell populations and follow treated cells for up to 2 cell cycle times. The model outputs quantify the changes in cell cycle dynamics following ionizing radiation treatment, principally in the duration of both Gi and G2/M phases.