Cross-scale multi-instance learning for pathological image diagnosis

Ruining Deng, Can Cui, Lucas W. Remedios, Shunxing Bao, R. Michael Womick, Sophie Chiron, Jia Li, Joseph T. Roland, Ken S. Lau, Qi Liu, Keith T. Wilson, Yaohong Wang, Lori A. Coburn, Bennett A. Landman, Yuankai Huo

Abstract: Highlights•A novel cross-scale MIL algorithm to explicitly model the inter-scale relationships.•Integrates multi-scale features with inter-scale knowledge.•Visualization of cross-scale attention produces scale-specific importance maps.•Superior performance by our simple cross-scale MIL strategy.•Investigate the efficacy of the multi-scale MIL paradigms with morphological patterns.