CFFormer: Cross CNN-Transformer channel attention and spatial feature fusion for improved segmentation of heterogeneous medical images

Published: 01 Jan 2026, Last Modified: 13 Nov 2025Expert Syst. Appl. 2026EveryoneRevisionsBibTeXCC BY-SA 4.0
Abstract: Highlights•CFFormer achieves outstanding segmentation performance, particularly on medical images with blurry boundaries and low contrast.•The proposed Cross Feature Channel Attention (CFCA) module enhances the model’s ability to selectively exchange information between feature maps across different encoder layers.•The proposed X-Spatial Feature Fusion (XFF) module effectively eliminates semantic discrepancies between encoders while enabling efficient feature integration.•CFFormer outperforms state-of-the-art (SOTA) methods across eight datasets spanning five different imaging modalities.
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