Multi-perspective neural network for dual drug repurposing in Alzheimer's disease

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Lu Zhao, Zhuojian Li, Guanxing Chen, Yiyang Yin, Calvin Yu-Chian Chen

Published: 2024, Last Modified: 29 Jul 2025Knowl. Based Syst. 2024EveryoneRevisionsBibTeXCC BY-SA 4.0
Abstract: Highlights•MNNEL-DTA integrates multi-view features: sequences, 3D structures, and interactions.•Achieved 9.2% & 8.9% improvement on Davis & KIBA, outperforming other SOTA models.•MNNEL-DTA offers visualization of attention weights, analyzing ensemble components.•Applied for AD drug repurposing, suggesting Glutethimide & Memantine as key drugs.