Style Content Decomposition-based Data Augmentation for Domain Generalizable Medical Image Segmentation

04 Nov 2025 (modified: 15 Dec 2025)MIDL 2026 Conference SubmissionEveryoneRevisionsBibTeXCC BY 4.0
Keywords: Medical Image Segmentation, Domain Generalization, Style Code, Content Map
TL;DR: Style Content Decomposition-based Data Augmentation for Domain Generalizable Medical Image Segmentation
Abstract: Due to domain shifts across diverse medical imaging modalities, learned segmentation models often suffer significant performance degradation during deployment. We posit that these domain shifts can be categorized into two main components: 1) "style" shifts, referring to global disparities in image properties such as illumination, contrast, and color; and "content" shifts, involving local discrepancies in anatomical structures. To address the domain shifts in medical image segmentation, we first factorize an image into style codes and content maps, explicitly modeling the "style" and "content" components. Building on this, we introduce a Style-Content decomposition-based data augmentation algorithm (StyCona), which performs augmentation on both the global style and local content of source-domain images, enabling the training of a well-generalized model for domain generalizable medical image segmentation. StyCona is a simple yet effective plug-and-play module that substantially improves model generalization without requiring additional training parameters or modifications to segmentation model architectures. Experiments on cardiac magnetic resonance imaging and fundus photography segmentation tasks, with single and multiple target domains respectively, demonstrate the effectiveness of StyCona and its superiority over state-of-the-art domain generalization methods. The code is available at https://github.com/Senyh/StyCona.
Primary Subject Area: Segmentation
Secondary Subject Area: Transfer Learning and Domain Adaptation
Registration Requirement: Yes
Reproducibility: https://github.com/Senyh/StyCona
Visa & Travel: Yes
Read CFP & Author Instructions: Yes
Originality Policy: Yes
Single-blind & Not Under Review Elsewhere: Yes
LLM Policy: Yes
Submission Number: 5
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