A Recommender System Approach for Predicting Effective Antivirals

Rafael Adorno, Diego Galeano, Diego H. Stalder, Luca Cernuzzi, Alberto Paccanaro

Abstract: Emerging infectious diseases such as COVID-19, caused by the SARS-CoV-2 virus, require systematic strategies to assist in the discovery of effective treatments. Drug repositioning, the process of finding new therapeutic indications for commercialized drugs, is a promising alternative to the development of new drugs, with lower costs and shorter development times. In this paper, we propose a recommendation system called geometric confidence non-negative matrix factorization (GcNMF) to assist in the repositioning of 126 broad spectrum antiviral drugs for 80 viruses, including SARS-CoV-2. GcNMF models the non-Euclidean structure of the space using graphs, and produces a ranked list of drugs for each virus. Our experiments reveal that GcNMF significanlty outperforms other matrix decomposition methods at predicting missing drug-virus associations. Our analysis suggests that GcNMF could assist pharmacological experts in the search for effective drugs against viral diseases.