Accurate and efficient cardiac digital twin from surface ECGs: Insights into identifiability of ventricular conduction system

Thomas Grandits, Karli Gillette, Gernot Plank, Simone Pezzuto

Abstract: Highlights•We construct cardiac digital twins (CDTs) using the 12-lead ECG and clinical imaging•Our CDTs are anatomically and electrophysiologically accurate•The construction of the CDT is orders of magnitude faster than existing methods•Our method scales excellently with the number of parameters•We quantify the uncertainty in the reconstruction