Fluctuations between high- and low-modularity topology in time-resolved functional connectivity

Makoto Fukushima, Richard F. Betzel, Ye He, Marcel A. de Reus, Martijn P. van den Heuvel, Xi-Nian Zuo, Olaf Sporns

Abstract: Highlights•Time-resolved functional connectivity in high/low modularity periods is investigated.•High modularity is tied to increased dissociation of task-positive/negative networks.•Low modularity is associated with heterogeneous connectivity patterns over time.•Frequency of high/low modularity periods has moderate inter-session reproducibility.•An interpretation of individual differences in long-timescale modularity is provided.