PathCNN: interpretable convolutional neural networks for survival prediction and pathway analysis applied to glioblastoma

Jung Hun Oh, Wookjin Choi, Euiseong Ko, Mingon Kang, Allen R. Tannenbaum, Joseph O. Deasy

Abstract: Convolutional neural networks (CNNs) have achieved great success in the areas of image processing and computer vision, handling grid-structured inputs and efficiently capturing local dependencies through multiple levels of abstraction. However, a lack of interpretability remains a key barrier to the adoption of deep neural networks, particularly in predictive modeling of disease outcomes. Moreover, because biological array data are generally represented in a non-grid structured format, CNNs cannot be applied directly.