Location-routing optimization problem of pharmaceutical cold chain logistics with oil-electric mixed fleets under uncertainties

Xiang Xu, Fen Li, Ting Wu, Xinru Huang, Xueling Guan, Tingyu Zheng, Liang Shen

Abstract: Highlights•Consideration of travel time reliability and energy consumption reliability in the optimization model.•Fuzzy logic is adopted to describe the uncertainty in pharmaceutical demand.•The NSGA-II is used to resolve the location-routing optimization problem for mixed fleets.•The proposed model and algorithm are validated on a real traffic road network.