Gene regulatory network inference methodology for genomic and transcriptomic data acquired in genetically related heterozygote individuals

Lise Pomiès, Céline Brouard, Harold Duruflé, Élise Maigné, Clément Carré, Louise Gody, Fulya Trösser, George Katsirelos, Brigitte Mangin, Nicolas B. Langlade, Simon de Givry

Abstract: Inferring gene regulatory networks in non-independent genetically related panels is a methodological challenge. This hampers evolutionary and biological studies using heterozygote individuals such as in wild sunflower populations or cultivated hybrids.