A Deep Learning based Pipeline for Efficient Oral Cancer Screening on Whole Slide Images

Jiahao Lu, Natasa Sladoje, Christina Runow Stark, Eva Darai Ramqvist, Jan-Michael Hirsch, Joakim Lindblad

Abstract: Oral cancer incidence is rapidly increasing worldwide. The most important determinant factor in cancer survival is early diagnosis. To facilitate large scale screening, we propose a fully automated pipeline for oral cancer detection on whole slide cytology images. The pipeline consists of fully convolutional regression-based nucleus detection, followed by per-cell focus selection, and CNN based classification. Our novel focus selection step provides fast per-cell focus decisions at human-level accuracy. We demonstrate that the pipeline provides efficient cancer classification of whole slide cytology images, improving over previous results both in terms of accuracy and feasibility. The complete source code is available at https://github.com/MIDA-group/OralScreen.