A robust Bayesian model to quantify and adjust for study quality and conflict of interest in meta-analyses

Matthias C. M. Troffaes, Lorenzo Casini, Jürgen Landes, Ullrika Sahlin

Abstract: Meta-analyses are vital for synthesizing evidence in medical research, but conflicts of interest can introduce research bias, undermining the reliability of the synthesized findings. This paper proposes a new robust Bayesian meta-analysis model. The model inflates uncertainty of low-quality studies and incorporates a bias term for studies subject to conflicts of interest. Using a random-effects model and sensitivity analysis with bounded probabilities, the model enables robust adjustments for conflicts of interest in meta-analytic contexts. A case study on antidepressant trials illustrates the potential application of the model.

External IDs:dblp:conf/isipta/TroffaesCLS25