Interpretable machine learning models for detecting peripheral neuropathy and lower extremity arterial disease in diabetics: an analysis of critical shared and unique risk factors

Ya Wu, Danmeng Dong, Lijie Zhu, Zihong Luo, Yang Liu, Xiaoyun Xie

Published: 2024, Last Modified: 28 Feb 2026BMC Medical Informatics Decis. Mak. 2024EveryoneRevisionsBibTeXCC BY-SA 4.0
Abstract: Diabetic peripheral neuropathy (DPN) and lower extremity arterial disease (LEAD) are significant contributors to diabetic foot ulcers (DFUs), which severely affect patients’ quality of life. This study aimed to develop machine learning (ML) predictive models for DPN and LEAD and to identify both shared and distinct risk factors.
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