Allele-specific multi-sample copy number segmentation in ASCAT

Edith M. Ross, Kerstin Haase, Peter Van Loo, Florian Markowetz

Abstract: Allele-specific copy number alterations are commonly used to trace the evolution of tumours. A key step of the analysis is to segment genomic data into regions of constant copy number. For precise phylogenetic inference, breakpoints shared between samples need to be aligned to each other.