Unseen Disease Detection for Deep Learning Interpretation of Chest X-raysDownload PDF

08 Feb 2021, 16:53 (modified: 22 Jul 2022, 19:57)MIDL 2021Readers: Everyone
Keywords: medical imaging, unseen disease detection, neural networks, deep learning, Chest X-ray
TL;DR: We systematically evaluate the performance of deep learning models in the presence of diseases not labeled for or present during training.
Abstract: We systematically evaluate the performance of deep learning models in the presence of diseases not labeled for or present during training. First, we evaluate whether deep learning models trained on a subset of diseases (seen diseases) can detect the presence of any one of a larger set of diseases. We find that models tend to falsely classify diseases outside of the subset (unseen diseases) as `no disease''. Second, we evaluate whether models trained on seen diseases can detect seen diseases when co-occurring with diseases outside the subset (unseen diseases). We find that models are still able to detect seen diseases even when co-occurring with unseen diseases. Third, we evaluate whether feature representations learned by models may be used to detect the presence of unseen diseases given a small labeled set of unseen diseases. We find that the penultimate layer provides useful features for unseen disease detection. Our results can inform the safe clinical deployment of deep learning models trained on a non-exhaustive set of disease classes.
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Paper Type: validation/application paper
Primary Subject Area: Detection and Diagnosis
Secondary Subject Area: Application: Radiology
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