Lymph Node Gross Tumor Volume Detection and Segmentation via Distance-Based Gating Using 3D CT/PET Imaging in Radiotherapy

Zhuotun Zhu, Dakai Jin, Ke Yan, Tsung-Ying Ho, Xianghua Ye, Dazhou Guo, Chun-Hung Chao, Jing Xiao, Alan L. Yuille, Le Lu

Abstract: Finding, identifying and segmenting suspicious cancer metastasized lymph nodes from 3D multi-modality imaging is a clinical task of paramount importance. In radiotherapy, they are referred to as Lymph Node Gross Tumor Volume (GTV $$_{LN}$$ ). Determining and delineating the spread of GTV $$_{LN}$$ is essential in defining the corresponding resection and irradiating regions for the downstream workflows of surgical resection and radiotherapy of various cancers. In this work, we propose an effective distance-based gating approach to simulate and simplify the high-level reasoning protocols conducted by radiation oncologists, in a divide-and-conquer manner. GTV $$_{LN}$$ is divided into two subgroups of “tumor-proximal" and “tumor-distal", respectively, by means of binary or soft distance gating. This is motivated by the observation that each category can have distinct though overlapping distributions of appearance, size and other LN characteristics. A novel multi-branch detection-by-segmentation network is trained with each branch specializing on learning one GTV $$_{LN}$$ category features, and outputs from multi-branch are fused in inference. The proposed method is evaluated on an in-house dataset of 141 esophageal cancer patients with both PET and CT imaging modalities. Our results validate significant improvements on the mean recall from $$72.5\%$$ to $$78.2\%$$ , as compared to previous state-of-the-art work. The highest achieved GTV $$_{LN}$$ recall of $$82.5\%$$ at $$20\%$$ precision is clinically relevant and valuable since human observers tend to have low sensitivity ( $$\sim $$ 80% for the most experienced radiation oncologists, as reported by literature [5]).