Thunderstruck: The ACDC model of flexible sequences and rhythms in recurrent neural circuits

Cristian Buc Calderon, Tom Verguts, Michael J. Frank

Abstract: Author summary How do humans flexibly adapt action sequences? For instance, musicians can learn a song and quickly speed up or slow down the tempo, or even play the song following a completely different rhythm (e.g., a rock song using a bossa nova rhythm). In this work, we build a biologically plausible network of cortico-basal ganglia interactions that explains how this temporal flexibility may emerge in the brain. Crucially, our model factorizes sequence order and action timing, respectively represented in cortical and basal ganglia dynamics. This factorization allows full temporal flexibility, i.e. the timing of a learned action sequence can be recomposed without interfering with the order of the sequence. As such, our model is capable of learning asynchronous action sequences, and flexibly shift, rescale, and recompose them, while accounting for biological data.