DiSC: Differential Spectral Clustering of Features

Ram Dyuthi Sristi, Gal Mishne, Ariel Jaffe

Keywords: differential features, spectral clustering, feature selection, manifold learning, graph theory

TL;DR: Developed a spectral based data-driven approach for detecting groups of features that differentiate between datasets/classes/conditions.

Abstract: Selecting subsets of features that differentiate between two conditions is a key task in a broad range of scientific domains. In many applications, the features of interest form clusters with similar effects on the data at hand. To recover such clusters we develop DiSC, a data-driven approach for detecting groups of features that differentiate between conditions. For each condition, we construct a graph whose nodes correspond to the features and whose weights are functions of the similarity between them for that condition. We then apply a spectral approach to compute subsets of nodes whose connectivity pattern differs significantly between the condition-specific feature graphs. On the theoretical front, we analyze our approach with a toy example based on the stochastic block model. We evaluate DiSC on a variety of datasets, including MNIST, hyperspectral imaging, simulated scRNA-seq and task fMRI, and demonstrate that DiSC uncovers features that better differentiate between conditions compared to competing methods.

Community Implementations: [ 1 code implementation](https://www.catalyzex.com/paper/disc-differential-spectral-clustering-of/code)