Abstract: Highlights•Two new frameworks, named as DHL and DBHL are proposed for COVID-19 detection in chest X-ray images.•DHL framework exploits the learning capacity of the developed COVID-RENets and SVM. COVID-RENet systematically learns the region homogeneity and boundaries features.•In the DBHL framework, rich information boosted representation is obtained by concatenating the feature space of the COVID-RENets.•The proposed frameworks significantly decrease false negatives as compared to existing deep CNNs.•A web predictor is developed for assisting the radiologist in making accurate COVID-19 decisions.
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