Gaussian-process-based Bayesian optimization for neurostimulation interventions in rats

Léo Choinière, Rose Guay-Hottin, Rémi Picard, Guillaume Lajoie, Marco Bonizzato, Numa Dancause

Abstract: Effective neural stimulation requires adequate parametrization. Gaussian-process (GP)-based Bayesian optimization (BO) offers a framework to discover optimal stimulation parameters in real time. Here, we first provide a general protocol to deploy this framework in neurostimulation interventions and follow by exemplifying its use in detail. Specifically, we describe the steps to implant rats with multi-channel electrode arrays in the hindlimb motor cortex. We then detail how to utilize the GP-BO algorithm to maximize evoked target movements, measured as electromyographic responses.