Abstract: The Storage Location Assignment Problem (SLAP) has a significant impact on the efficiency of warehouse operations. We propose a multi-phase optimizer for the SLAP, where the quality of an assignment is based on distance estimates of future-forecasted order-picking. Candidate assignments are first sampled using a Markov Chain accept/reject method. Order-picking Traveling Salesman Problems (TSPs) are then modified according to the assignments and solved. The model is graph-based and generalizes to any obstacle layout in two dimensions. We investigate whether optimization speed-ups are possible using methods such as cost approximation, rejection of samples with low approximate cost and restarts from local minima. Results demonstrate that these methods improve performance, with total travel-cost reductions of up to 30% within 8 h of CPU-time. We share a public repository with SLAP instances and corresponding benchmark results on the generalizable TSPLIB format.