Harnessing topological machine learning in Raman spectroscopy: Perspectives for Alzheimer's disease detection via cerebrospinal fluid analysis

Francesco Conti, Martina Banchelli, Valentina Bessi, Cristina Cecchi, Fabrizio Chiti, Sara Colantonio, Cristiano D'Andrea, Marella de Angelis, Davide Moroni, Benedetta Nacmias, Maria Antonietta Pascali, Sandro Sorbi, Paolo Matteini

Abstract: Highlights•Introduce Topological Machine Learning (TML) for analysis of Raman Spectroscopy data.•Prove TML validity in Alzheimer’s detection using cerebrospinal fluid analysis.•Show that the TML pipeline excells in Alzheimer’s detection, compared to classical and deep models.