Benchmarking Large Language Models on Safety Risks in Scientific Labs

Yujun Zhou, Jingdong Yang, Yue Huang, Kehan Guo, Zoe Emory, Bikram Ghosh, Amita Bedar, Sujay Shekar, Zhenwen Liang, Pinyu chen, Tian Gao, Werner Geyer, Nitesh V Chawla, Xiangliang Zhang

Keywords: Benchmark, Lab Safety, Large Language Models

Abstract: Artificial Intelligence (AI) is revolutionizing scientific research, yet its growing integration into laboratory environments presents critical safety challenges. Large language models (LLMs) and vision–language models (VLMs) now assist in experiment design and procedural guidance, yet their “illusion of understanding” may lead researchers to overtrust unsafe outputs. Here we show that current models remain far from meeting the reliability needed for safe laboratory operation. We introduce LabSafety Bench, a comprehensive benchmark that evaluates models on hazard identification, risk assessment, and consequence prediction across 765 multiple-choice questions and 404 realistic lab scenarios, encompassing 3,128 open-ended tasks. Evaluations on 19 advanced LLMs and VLMs show that no model evaluated on hazard identification surpasses 70\% accuracy. While proprietary models perform well on structured assessments, they do not show a clear advantage in open-ended reasoning. These results underscore the urgent need for specialized safety evaluation frameworks before deploying AI systems in real laboratory settings.

Submission Number: 14