Logarithmic total variation regularization via preconditioned conjugate gradient method for sparse reconstruction of bioluminescence tomography

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Gege Zhang, Jun Zhang, Yi Chen, Mengfei Du, Kang Li, Linzhi Su, Huangjian Yi, Fengjun Zhao, Xin Cao

Published: 2024, Last Modified: 28 Jan 2026Comput. Methods Programs Biomed. 2024EveryoneRevisionsBibTeXCC BY-SA 4.0
Abstract: Highlights•A novel PCG-logTV method is proposed for sparse reconstruction of BLT, which combines TV regularization and logarithm function.•The method reduces the ill-posedness of BLT reconstruction and avoids the staircase artifacts of TV solutions.•The method is validated by numerical simulations and in vivo experiment, and shows superior performance over other methods.•The method enhances the quality and accuracy of BLT reconstruction and facilitates various preclinical applications of BLT.