LPUWF-LDM: Enhanced latent diffusion model for precise late-phase UWF-FA generation on limited dataset

Zhaojie Fang, Xiao Yu, Guanyu Zhou, Ke Zhuang, Yifei Chen, Ruiquan Ge, Changmiao Wang, Gangyong Jia, Qing Wu, Juan Ye, Maimaiti Nuliqiman, Peifang Xu, Ahmed Elazab

Abstract: Highlights•A diffusion model that generates late-phase Ultra-Wide-Field Fluorescein Angiography.•Enhanced Variational Autoencoder for cross-modal generation on limited data.•A suitable noise strategy for ophthalmic image distribution in diffusion process.•A loss function that promotes model to focus on lesion areas unsupervisedly.