Left Ventricular Shape and Motion Reconstruction Through a Healthy Model for Characterizing Remodeling After Infarction

Mathieu De Craene, Paolo Piro, Nicolas Duchateau, Pascal Allain, Eric Saloux

Abstract: We introduce a framework for the statistical characterization of heart remodeling from both shape and dynamics of the left ventricle. Shape was characterized by thickness and radius maps, unfolded in a two-dimensional dense Bull’s eye. Motion was represented as a mixture of affine transformations in an anatomical space of coordinates. Using this representation, a population can be projected (after defining spatiotemporal correspondences) to an atlas space built for a given reference population - here, healthy subjects using a classic PCA approach - yielding a joint model of healthy shape and motion statistics. The reconstruction error on shape and motion can then be exploited to quantify remodeling abnormalities. We demonstrate these concepts on 48 healthy subjects and 62 patients with infarct (29 with one year follow-up) imaged with 3D echocardiography, analyzing a total of 139 sequences.