Reliability of functional magnetic resonance imaging activation during working memory in a multi-site study: Analysis from the North American Prodrome Longitudinal Study

Jennifer K. Forsyth, Sarah C. McEwen, Dylan G. Gee, Carrie E. Bearden, Jean Addington, Brad Goodyear, Kristin S. Cadenhead, Heline Mirzakhanian, Barbara A. Cornblatt, Doreen M. Olvet, Daniel H. Mathalon, Thomas H. McGlashan, Diana O. Perkins, Aysenil Belger, Larry J. Seidman, Heidi W. Thermenos, Ming T. Tsuang, Theo G. M. van Erp, Elaine F. Walker, Stephan Hamann et al. (3 additional authors not shown)

Abstract: Highlights•We examined reliability of fMRI during a working memory task in a multi-site study.•Greater variance due to person than site factors in variance component analysis.•Reliability coefficients showed excellent reliability for person effect in primary ROIs.•Two methods for aggregating data across sites produced similar activation maps.•Implications for design and implementation of multi-site fMRI studies.