Efficient encoding of motion is mediated by gap junctions in the fly visual system

Siwei Wang, Alexander Borst, Noga Zaslavsky, Naftali Tishby, Idan Segev

Abstract: Author summary Understanding sensory stimuli from the environment and deciding how best to respond to it behaviorally is essential for survival. What makes organisms efficient in encoding these sensory stimuli? This study provides a novel view on this unresolved issue using the visual system of the fly. We show that a specific synaptic connectivity manifested via gap junctions (GJs) among axons in the Vertical System (VS) network leads to particularly high encoding efficiency of the axis of rotation of the fly’s ego motion. Due to these GJs, triplets of VS neurons (the VS5-6-7 triplet), which connect to a downstream motor system, encode motion stimuli at an efficiency close to the physical limit; this efficient encoding is necessary for evasive maneuvers that are critical for the fly to escape predators. We then suggest why GJs in the VS network enable such high encoding efficiency.