Abstract: Highlights•Innovative Network Design: Design of DSIFNet for precise and automatic segmentation of nasal cavity and vestibule from 3D CT.•Advanced Feature Extraction: Incorporation of the LGPI-IFF to enhance cross-scale feature extraction and fusion.•Novel Deep Supervision Framework: The deep supervision framework based on LGPI-IFF optimizes multi-scale feature utilization.•Extensive Dataset: Construction of a dataset with 7116 CT for pretraining and 128 annotated CT for training and evaluation.•SOTA Performance: Achieved high accuracy and robustness in nasal cavity and vestibule segmentation via cross-validation.
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