OLOGRAM: determining significance of total overlap length between genomic regions sets

Q. Ferré, G. Charbonnier, N. Sadouni, Frédéric Lopez, Y. Kermezli, Salvatore Spicuglia, Cécile Capponi, Badih Ghattas, Denis Puthier

Abstract: Various bioinformatics analyses provide sets of genomic coordinates of interest. Whether two such sets possess a functional relation is a frequent question. This is often determined by interpreting the statistical significance of their overlaps. However, only few existing methods consider the lengths of the overlap, and they do not provide a resolutive P-value.