Improving Phase-Rectified Signal Averaging for Fetal Heart Rate Analysis

Tong Chen, Guanchao Feng, Cassandra Heiselman, J. Gerald Quirk, Petar M. Djuric

Abstract: Low umbilical artery pH is a marker for neonatal acidosis and is associated with an increased risk for neonatal complications. Phase-rectified signal averaging (PRSA) features have demonstrated superior discriminatory or diagnostic ability and good interpretability in many biomedical applications including fetal heart rate analysis. However, the performance of PRSA-based methods is sensitive to values of the selected parameters which are usually either chosen based on a grid search or empirically in the literature. In this paper, we examine PRSA-based methods through the lens of dynamical systems theory and reveal the intrinsic connection between state space reconstruction and PRSA. From this perspective, we then introduce a new feature that can better characterize comparisons of dynamical systems with PRSA. Our experimental results on an open-access intrapartum Cardiotocography database demonstrate that the proposed feature outperforms state-of-the-art PRSA features in pH-based fetal heart rate analysis.