Modulation of cortical slow oscillations and complexity across anesthesia levels

Miguel Dasilva, Alessandra Camassa, Alvaro Navarro-Guzman, Antonio Pazienti, Lorena Perez-Mendez, Gorka Zamora-López, Maurizio Mattia, Maria V. Sanchez-Vives

Abstract: Highlights•We study how cortical complexity builds up from deep to lighter anesthesia.•The cortical dynamic regime is a bistable state consisting of slow oscillations.•Spontaneous cortical dynamics is quantified by wave propagation/functional complexity.•We compare with perturbational complexity index as used in the clinics.•Cortical complexity increases in lighter anesthesia even in slow oscillatory regime.