ARCANE-ROG: Algorithm for reconstruction of cancer evolution from single-cell data using robust graph learning

Download PDF
Open Webpage

Akanksha Farswan, Ritu Gupta, Anubha Gupta

Published: 01 Jan 2022, Last Modified: 17 Feb 2025J. Biomed. Informatics 2022EveryoneRevisionsBibTeXCC BY-SA 4.0
Abstract: Highlights•Propose ARCANE-ROG, a robust graph learning-based method for single-cell data.•Reconstructs cancer evolution from single-cell DNA data.•ARCANE-ROG has improved cluster assignment and inference on clonal hierarchies.•Leiden algorithm is used to find an optimal number of clusters in the data.•Validated using 1000 simulated datasets of varying sizes and five real datasets.