Retrieval-Augmented Multiple Instance Learning

Yufei CUI, Ziquan Liu, Yixin CHEN, Yuchen Lu, Xinyue Yu, Xue Liu, Tei-Wei Kuo, Miguel R. D. Rodrigues, Chun Jason Xue, Antoni B. Chan

Keywords: Multiple Instance Learning, Whole Slide Imaging, Nearest Neighbor Retrieval

TL;DR: Augmenting multiple instance learning with optimal Transport-based retrieval achieves state-of-the-art performance in both in-domain and out-of-domain whole slide image classification.

Abstract: Multiple Instance Learning (MIL) is a crucial weakly supervised learning method applied across various domains, e.g., medical diagnosis based on whole slide images (WSIs). Recent advancements in MIL algorithms have yielded exceptional performance when the training and test data originate from the same domain, such as WSIs obtained from the same hospital. However, this paper reveals a performance deterioration of MIL models when tested on an out-of-domain test set, exemplified by WSIs sourced from a novel hospital. To address this challenge, this paper introduces the Retrieval-AugMented MIL (RAM-MIL) framework, which integrates Optimal Transport (OT) as the distance metric for nearest neighbor retrieval. The development of RAM-MIL is driven by two key insights. First, a theoretical discovery indicates that reducing the input's intrinsic dimension can minimize the approximation error in attention-based MIL. Second, previous studies highlight a link between input intrinsic dimension and the feature merging process with the retrieved data. Empirical evaluations conducted on WSI classification demonstrate that the proposed RAM-MIL framework achieves state-of-the-art performance in both in-domain scenarios, where the training and retrieval data are in the same domain, and more crucially, in out-of-domain scenarios, where the (unlabeled) retrieval data originates from a different domain. Furthermore, the use of the transportation matrix derived from OT renders the retrieval results interpretable at the instance level, in contrast to the vanilla $l_2$ distance, and allows for visualization for human experts. *Code can be found at \url{https://github.com/ralphc1212/ram-mil*.

Submission Number: 8098