Brain Harmony: A Multimodal Foundation Model Unifying Morphology and Function into 1D Tokens

Zijian Dong, Li Ruilin, Joanna Su Xian Chong, Niousha Dehestani, Yinghui Teng, Yi Lin, Zhizhou Li, Yichi Zhang, Yapei Xie, Leon Qi Rong Ooi, B.T. Thomas Yeo, Juan Helen Zhou

Keywords: Multimodal Neuroimaging; Brain Foundation Model; 1D Tokens; Representation Learning; Neuropsychiatric Disorders; Cognition

TL;DR: Brain Harmony (BrainHarmonix) unifies T1 MRI + fMRI into 1D tokens and tops six brain-disorder benchmarks.

Abstract: We present **Brain Harmony (BrainHarmonix)**, the first multimodal brain foundation model that unifies structural morphology and functional dynamics into compact 1D token representations. The model was pretrained on two of the largest neuroimaging datasets to date, encompassing 64,594 T1-weighted structural MRI 3D volumes (～ 14 million images) and 70,933 functional MRI (fMRI) time series. BrainHarmonix is grounded in two foundational neuroscience principles: *structure complements function* - structural and functional modalities offer distinct yet synergistic insights into brain organization; *function follows structure* - brain functional dynamics are shaped by cortical morphology. The modular pretraining process involves single-modality training with geometric pre-alignment followed by modality fusion through shared brain hub tokens. Notably, our dynamics encoder uniquely handles fMRI time series with heterogeneous repetition times (TRs), addressing a major limitation in existing models. BrainHarmonix is also the first to deeply compress high-dimensional neuroimaging signals into unified, continuous 1D tokens, forming a compact latent space of the human brain. BrainHarmonix achieves strong generalization across diverse downstream tasks, including neurodevelopmental and neurodegenerative disorder classification and cognition prediction - consistently outperforming previous approaches. Our models - pretrained on 8 H100 GPUs - aim to catalyze a new era of AI-driven neuroscience powered by large-scale multimodal neuroimaging.

Primary Area: Neuroscience and cognitive science (e.g., neural coding, brain-computer interfaces)

Submission Number: 14986