Trans-channel fluorescence learning improves high-content screening for Alzheimer's disease therapeutics

Daniel R. Wong, Jay Conrad, Noah R. Johnson, Jacob Ayers, Annelies Laeremans, Joanne C. Lee, Jisoo Lee, Stanley B. Prusiner, Sourav Bandyopadhyay, Atul J. Butte, Nick A. Paras, Michael J. Keiser

Abstract: Fluorescent markers in microscopy-based drug screens carry information on how compounds affect biological processes, but practical considerations may hinder their use. Wong et al. develop a deep learning method for generating images in drug discovery, with broad applicability across diverse fluorescence microscopy datasets.