On the Potentials of Utilizing a Handheld Bioprinter for in Vivo Treatment of Volumetric Muscle Loss Injuries

Omid Rezayof, Susheela Sharma, Meenakshi Kamaraj, Johnson v. John, Farshid Alambeigi

Abstract: In this study, with the goal of enhancing and evaluating existing treatment procedures for large Volumetric Muscle Loss (VML) injuries, we propose design and quantitative performance evaluation of a handheld in vivo bioprinter. Existing bioprinting handheld devices are either have been used for treatment of small injuries or miss to quantitatively verify the precision and accuracy of printing procedure and limited these evaluations to qualitative analysis. To simultaneously address these issues, in this work, we first proposed design and development of a bioprinting system. Next, to quantitatively address the accuracy of the developed handheld device, we first proposed a calibration procedure and then performed a set of experiments to quantitatively evaluate and characterize the performance of printing with this device.