Prostate Cancer Diagnosis and Grading in Whole Slide Images of Core Needle BiopsiesDownload PDF

22 Apr 2022, 15:40 (modified: 04 Jun 2022, 12:07)MIDL 2022 Short PapersReaders: Everyone
Keywords: Prostate, cancer, domain agnostic, histopathology, deep learning, active learning
TL;DR: Prostate Cancer Grading of Core Needle Biopsies
Abstract: Gleason grading is a risk stratification procedure for prostate cancer that is subjective and based on the reporting pathologist's experience and skill. Deep Learning (DL) algorithms have showed potential in improving Gleason grading objectivity and efficiency. On Whole Slide Images (WSI) from a source other than training data, however, DL networks show domain shift and poor performance. Using a novel training process that learns domain agnostic features, we propose a DL approach for segmenting and grading epithelial tissue. When utilised as an aid for core needle biopsy (CNB) evaluation, our DL approach has the potential to increase grading consistency and accuracy, leading in better patient outcomes.
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Paper Type: recently published or submitted journal contributions
Primary Subject Area: Validation Study
Secondary Subject Area: Application: Histopathology
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