Investigating the Large Language Models' Awareness of Changing Medical Knowledge

ACL ARR 2025 May Submission8024 Authors

Abstract: The growing capabilities of Large Language Models (LLMs) can enhance healthcare by assisting medical researchers, physicians, and improving access to health services for patients. LLMs encode extensive knowledge within their parameters, including medical knowledge derived from many sources. However, the knowledge in LLMs can become outdated over time, posing challenges in keeping up with evolving medical recommendations and research. This can lead to LLMs providing outdated health advice or failures in medical reasoning tasks. To address this gap, our study introduces two novel biomedical question-answering (QA) datasets derived from medical systematic literature reviews: MedRevQA, a general dataset of 16,501 biomedical QA pairs, and MedChangeQA, a subset of 512 QA pairs whose verdict changed though time. By evaluating the performance of eight popular LLMs, we find that all models exhibit memorization of outdated knowledge to some extent. We provide deeper insights and analysis, paving the way for future research on this challenging aspect of LLMs.

Paper Type: Short

Research Area: NLP Applications

Research Area Keywords: healthcare applications, clinical NLP, fact-checking

Contribution Types: NLP engineering experiment, Data resources, Data analysis

Languages Studied: English

Submission Number: 8024