Hierarchical graph representation learning for the prediction of drug-target binding affinity

Zhaoyang Chu, Feng Huang, Haitao Fu, Yuan Quan, Xionghui Zhou, Shichao Liu, Wen Zhang

Abstract: Highlights•A novel hierarchical graph representation learning model for drug-target binding affinity prediction.•Represents the drug-target binding affinity data as a hierarchical graph.•Hierarchically integrates coarse- and fine-level information in a coarse-to-fine manner.