Magnification Prior: A Self-Supervised Method for Learning Representations on Breast Cancer Histopathological Images

Prakash Chandra Chhipa, Richa Upadhyay, Gustav Grund Pihlgren, Rajkumar Saini, Seiichi Uchida, Marcus Liwicki

Abstract: This work presents a novel self-supervised pre-training method to learn efficient representations without labels on histopathology medical images utilizing magnification factors. Other state-of-the-art works mainly focus on fully supervised learning approaches that rely heavily on human annotations. However, the scarcity of labeled and unlabeled data is a long-standing challenge in histopathology. Currently, representation learning without labels remains unexplored in the histopathology domain. The proposed method, Magnification Prior Contrastive Similarity (MPCS), enables self-supervised learning of representations without labels on small-scale breast cancer dataset BreakHis by exploiting magnification factor, inductive transfer, and reducing human prior. The proposed method matches fully supervised learning state-of-the-art performance in malignancy classification when only 20% of labels are used in fine-tuning and outperform previous works in fully supervised learning settings for three public breast cancer datasets, including BreakHis. Further, It provides initial support for a hypothesis that reducing human-prior leads to efficient representation learning in self-supervision, which will need further investigation. The implementation of this work is available online on GitHub <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sup> .